منابع مشابه
Mutagenicity and anti-mutagenicity of selected spices.
Using Salmonella typhimurium strains TA 100 and TA 1535, the mutagenicity and anti-mutagenicity of extracts of several spices were checked. Spices like pepper, pippali, ginger and mustard increased the number of revertants indicating their mutagenic potential. Garlic extract on the other hand was found to inhibit the mutagenicity produced by direct acting mutagens such as N-methyl N'-nitro-N-ni...
متن کاملMutagenicity of Azathioprine1
Azathiopnine was without significant mutagenic potential (Table 1, Experiment 1) when exposure of the bacteria to the drug was carried out under the standard procedure developed by Ames et a!. (1, 3). However, when the initial exposure of the bacteria to the test agent was allowed to occur under anaerobic conditions, a mutagenic effect was cleanly demonstrable (Table 1, Experiment 1). This effe...
متن کاملon Frameshift Mutagenicity
Some derivatives ot' 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding aMnity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding aMnity, whjle {he introdu ¢ tion of chlorine increased them. Halogenated derivatSyes f 1 showed higher toxicity against Saintonella mphiinu...
متن کاملPrediction of Salmonella mutagenicity.
The ability of a number of prediction systems was examined to determine how well they could predict Salmonella mutagenicity. The prediction systems included two computer-based systems (CASE and TOPKAT), the measurement of a physiochemical parameter (ke) and the use of structural alerts by an expert chemist. The computer-based systems operators and the chemist were supplied with the structures o...
متن کاملMutagenicity in gastric juice.
Mutagenicity has been measured in the gastric juice of 228 patients using the Ames bacteriological test system; while mutagenicity in control and duodenal ulcer patients did not differ from saline controls, mutagenicity was significantly increased compared with controls in patients suffering gastric ulcer (p less than 0.002), carcinoma (p less than 0.002), and in patients after gastric resectio...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1977
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)60585-8